2022-12-072022-12-072009ALENCAR, Lecidio da Silva; CAVALCANTE, Paula Jorgiane Leitão. Síndrome de Apert: relato de dois casos e revisão de literatura. Orientadora: Isabel Cristina Neves de Souza. 2009. 47 f. Trabalho de Curso (Bacharelado em Medicina)-Faculdade de Medicina, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, 2009. Disponível em: https://bdm.ufpa.br:8443/jspui/handle/prefix/4801. Acesso em:.https://bdm.ufpa.br/handle/prefix/4801Apert's syndrome is the type I acrocephalosyndactyly. It was described by Apert, and is characterized by craniosynostosis with fusion of the cranial sutures and / or its base, associated with maxillary hypoplasy, symmetrical syndactyly of hands and feet and other systemic malformations. Mental deficiency is considered common for patients with Apert’s syndrome and may be due to brain malformations, high intracranial pressure or family inheritance. It is one of the five craniosynostosis syndromes caused by mutations in alleles of growth factor for fibroblasts receptor 2. The advanced paternal age has been implicated in reproductive and genetic changes. The treatment of these patients is done in multidisciplinary order. Surgical planning should be done in stages, where the purpose of decompression craniotomy in brain should be performed in childhood. Correction of syndactyly and other deformities can also be performed. To describe the case of two children with Apert syndrome, contributing to the knowledge of disease and facilitating its diagnosis. Apert’s syndrome can be evidenced by physical examination. Genetic counseling is indicated. The prognosis depends on the severity of malformations.Acesso AbertoAcrocefalossindactiliaSíndrome de ApertGenéticaAcrocephalosyndactylyApert’s syndromeGeneticsCNPQ::CIENCIAS DA SAUDE::MEDICINATrabalho de Curso - Graduação - Monografia