2026-09-042026-09-042020-09-30BALBINOT, Karolyny Martins. Imunoexpressão dos marcadores de células-tronco SOX-2, NANOG E OCT4 em Ameloblastoma. Orientador: João de Jesus Viana Pinheiro. 2020. 40 f. Trabalho de Curso (Bacharelado em Odontologia) – Faculdade de Odontologia, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, 2020. Disponível em: https://bdm.ufpa.br/handle/prefix/10119. Acesso em:.https://bdm.ufpa.br/handle/prefix/10119Ameloblastoma is characterized by a slow growth pattern, however, locally invasive, with a propensity for local recurrence. In the search for cellular mechanisms that justify such progression, the investigation of the role of stem cells and their relationship with cancer cells has gained prominence in tumor biology, with studies relating their participation in the growth, progression and recurrence of tumors. To analyze the presence of stem cells, the literature points out some important biomarkers, such as SOX-2, NANOG and OCT4, which are considered to be critical regulators of embryonic self-renewal and pluripotency capable of mediating tumor initiation, proliferation and differentiation. Thus, the aim of this study is to analyze, using immunohistochemistry, the expression of proteins related to the activity of stem cells in ameloblastoma. Ameloblastoma samples showed statistically significant marking of biomarkers when compared with dentigerous cyst and dental follicle (p <0.001), with a correlation of the immunostained area of OCT4 and SOX-2 proteins in ameloblastoma neoplastic cells (r = 0.4544), as well as a positive linear relationship between OCT4 and SOX-2 staining in ameloblastoma neoplastic cells (r² = 0.2065). The immunostaining of the proteins studied in ameloblastoma indicates the probable role of stem cells in the genesis and progression of this neoplasm.Acesso AbertoAmeloblastomaCélulas-troncoFatores de transcriçãoSOXFatores de transcrição de OctâmeroImuno-histoquímicaAmeloblastomaStem CellsTranscription factorsOctamer Transcription FactorsImmunohistochemistryCNPQ::CIENCIAS DA SAUDE::ODONTOLOGIATrabalho de Curso - Graduação - MonografiaAttribution-NonCommercial-NoDerivs 3.0 Brazil