2026-09-092026-09-092020-09-30SENA, Yasmim Rodrigues. Silenciamento das proteínas TKS4 e TKS5 relacionadas à formação de Invadopódio e o processo de invasão no tumor Odontogênico Ameloblastoma. Orientador: João de Jesus Viana Pinheiro; Coorientadora: Sâmia Cordovil de Almeida. 2020. f. Trabalho de Curso (Bacharelado em Odontologia) – Faculdade de Odontologia, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, 2020. Disponível em: https://bdm.ufpa.br/handle/prefix/10157. Acesso em:.https://bdm.ufpa.br/handle/prefix/10157Ameloblastoma (AME) is a benign odontogenic tumour, of epithelial origin and slow growth, but it presents local invasiveness and high recurrence rates. In view of the aggressiveness and recurrence of this tumour, the processes that contribute to the invasiveness of the lesion are investigated, attributed, in part, to the degradation capacity of the extracellular matrix (ECM). Enhanced studies that the dynamic protrusions of the plasma membrane, called invadopodia, can be strongly related to the degradation of the ECM, being the group of TKs proteins key molecules for the formation of invadopodia. In view of the promotion of this neoplasm, its aggressiveness and capacity for local invasion, studies that seek to understand the biological processes of this tumour are essential for future treatments and better prognosis to be achieved. Therefore, the objective of this work was to verify the participation of TKs4 and TKs5 proteins in the invasion process, in ameloblastoma cell line. The methods used were Cell culture, RNA silencing (shRNA), Real-time Polymerase Chain Reaction (RT-PCR) and Cell invasion assay. The results revealed a decrease in the invasiveness of cells treated with TKs4 and TKs5 shRNA, when compared to cells in the control group, indicating that possibly these genes have an important role in local invasion of ameloblastoma.Acesso AbertoAmeloblastomaInvadopódioInvasividade neoplásicaInvadopodiaNeoplastic invasivenessCNPQ::CIENCIAS DA SAUDE::ODONTOLOGIATrabalho de Curso - Graduação - ArtigoAttribution-NonCommercial-NoDerivs 3.0 Brazil