2026-06-112026-06-112024-10-04BOTELHO, Juliana Campos. Avaliação de variantes genéticas e o risco de câncer oral: achados de revisão sistemática com abordagem bayesiana. Orientador: Felipe Rodolfo Pereira da Silva. 2024. 46 f. Trabalho de Curso (Bacharelado em Medicina) - Faculdade de Medicina, Campus Universitário de Altamira, Universidade Federal do Pará, Altamira, 2024. Disponível em: https://bdm.ufpa.br/handle/prefix/9599. Acesso em:.https://bdm.ufpa.br/handle/prefix/9599Introduction: Oral neoplasms encompass various tumors in the oral cavity, with squamous cell carcinoma being the most common, accounting for 90% of cases. In 2022, oral cancer had 389,846 new cases and 188,438 deaths, with an estimated annual increase of 2% by 2030. Risk factors include smoking, alcohol consumption, and HPV infections. Studies also associate genetic variations and immune mediators with disease risk, with meta-analyses helping to understand the role of these genetic variants in oral cancer. Objective: This study aimed at assessing the level of false-positive rates by means of a Bayesian approach in meta-analytic data on genetic variations in immune mediator genes related with oral cancer risk. Material and methods: A systematic search was performed for meta-analyses in this field that were published before April 2, 2024, in several medical databases. The calculations for the False- Positive Rate Probability (FPRP) and the Bayesian False Discovery Probability (BFDP) were performed to assess the noteworthiness with a statistical power of 1.2 and 1.5 of Odds Ratio at a prior probability of 10-3 and 10-6. In addition, a methodological evaluation was performed by Venice Criteria evaluation and gene-gene and protein-protein networks were designed as in silico analyses. Results: As results, ten meta-analyses approaching the TNFA/rs361625/rs1800629, GF/rs3025039, IL4/rs2070874, IL6/rs1800795, IL8/rs4073, and IL10/rs1800896 genes/polymorphisms have been included. 88 significant OR association values from the included meta-analysis allowed the performance of 336 calculations for FPRP and 176 for BFDP. We found 35 noteworthy values (10.42%) for FPRP and 59 noteworthy values (33.52%) for BFDP that demonstrated the variants in VEGF and IL10 with noteworthiness association with oral cancer. The gene-gene and protein-protein networksAcesso AbertoNeoplasias oraisCitocinaFatores de riscoAlelosOral neoplasmsCytokineRisk factorsAllelesCNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA::CANCEROLOGIATrabalho de Curso - Graduação - Monografia