2026-09-042026-09-042020-09-30ROSA, Karina Pereira. Expressão in vitro das proteínas chave na formação do Invadopódio: Cortactina, MT1-MMP, TKS4 E TKS5 no tumor Odontogênico Ameloblastoma. Orientador: João de Jesus Viana Pinheiro; Coorientadora: Sâmia Cordovil de Almeida. 2020. 46 f. Trabalho de Curso (Bacharelado em Odontologia) – Faculdade de Odontologia, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, 2020. Disponível em: https://bdm.ufpa.br/handle/prefix/10118. Acesso em:.https://bdm.ufpa.br/handle/prefix/10118Ameloblastoma (AME) is an epitelial odontogenic tumor that presentes slow growth, local invasiveness, and high rates of recurrence. Studies show that invasiveness of AME is associated to invadopodias, which are cell-membrane protrusions with pericellular proteolytic activity. Some proteins are related to formation of invadopodia: cortactin, which is induced by TKs5, and changes the cell cytoskeleton, and MT1- MMP, which is induced by TKs4 and is responsable for ECM proteolysis. The objective of this work is to verify the expression of proteins related to invadopodia: cortactin, TKs5, TKs4 and MT1-MMP in cell line AME-hTERT. For this, immunofluorescence assays were performed, that confirm the expression of these proteins in cell line AME-hTERT. The presence of these proteins in AME are favors to the idea that invadopodias are related to ameloblastoma’s invasiveness.Acesso AbertoAmeloblastomaInvadopódiosTKs4TKs5CortactinaMT1-MMPCortactinCNPQ::CIENCIAS DA SAUDE::ODONTOLOGIATrabalho de Curso - Graduação - MonografiaAttribution-NonCommercial-NoDerivs 3.0 Brazil