2023-05-022023-05-022022SILVA, Maria Samara Alves da; CARVALHO, Thayane Picanço de. Análise clínica e epidemiológica da síndrome de resposta inflamatória multissistêmica causada pela covid-19 em crianças no estado do Pará. Orientadora: Carla Andrea Avelar Pires. 2022. 62 f. Trabalho de Curso (Bacharelado em Medicina)-Faculdade de Medicina, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, 2022. Disponível em: https://bdm.ufpa.br:8443/jspui/handle/prefix/5584. Acesso em:.https://bdm.ufpa.br/handle/prefix/5584Introduction: Cases of Multisystem Inflammatory Syndrome in Children (MIS­C) potentially associated with COVID­19 began to be reported in April 2020. This syndrome has similar manifestations to Kawasaki Syndrome and many children may present complete or incomplete criteria for this syndrome, which occurs mostly in older pediatric patients, adolescents and schoolchildren, who have markers of inflammation, of coagulopathy and of myocardial injury elevated. It is a pathology that involves at least two organs or systems. The main ones being cardiac, respiratory, renal, hematological, dermatological, gastrointestinal or neurological. Objective: Analyze the occurrence of Multisystem Inflammatory Syndrome in Children associated with COVID­19 in children from the state of Pará from april 2020 to august 2021. Method: This is a cross­sectional descriptive epidemiological study in which information from the secondary database of notifications of Multisystem Inflammatory Syndrome in Children (MIS­C) of the Secretaria de Saúde Pública do Pará (SESPA) was used. Results: 40 cases affected by MIS­C were analyzed in Pará. 31 (78%) were diagnosed with COVID­19 through laboratory criteria and 9 (22%) through epidemiological criteria. The age ranged from 3 months to 13 years, with a median of 3.5 years. The majority of the population studied was between 0 and 2 years old (lactants), corresponding to 16 cases (40%). The majority occurred in the male sex, corresponding to 26 cases (65%). The municipalities with the highest number of confirmed cases were Belém with 20 cases (50%); Barcarena with 3 cases (7.5%) and Castanhal also with 3 cases (7.5%). The diagnostic criteria for MIS­C associated with COVID­19 that appeared the most were fever greater than 38°C for 3 days or more, present in 40 cases (100%); elevation of inflammatory markers in 39 cases (97.5%); evidence of COVID­19 or history of close contact with a confirmed case of COVID­19 in 39 cases (97.5%). The most frequent symptoms were diarrhea (62.5%); cough (47.5%); nausea and vomiting (45%) and abdominal pain (45%). As for laboratory alterations, inflammatory markers were the most altered. There was a need for admission to the Intensive Care Unit in 52% of cases. About the treatment performed in patients in an ICU bed, the most used drug classes were corticosteroids in 76.19% and anticoagulants in 57.14%. There were 5 deaths among the patients who needed ICU support. Of these, 4 had comorbidities. Conclusion: Although most children and adolescents do not progress seriously during COVID­19, it was found that after infection by the virus, these patients can evolve with an exacerbated immune system response, resulting in a multisystem inflammatory syndrome. This study points to important results for the planning of health actions for the management of MIS­C, through the provision of information about whether are the patients who evolved with MIS­C¸ presence of previous comorbidities, treatment they performed, in addition to their outcomes of the condition.Acesso AbertoCOVID-19PediatriaSíndrome inflamatória multissistêmica (SIM­P)PediatricsMultisystem inflammatory syndrome in children (MIS­C)CNPQ::CIENCIAS DA SAUDE::MEDICINATrabalho de Curso - Graduação - Monografia