2024-07-042024-07-042023-12-15SENA, Diego de Sousa; ANDRADE, Geovana Helena Lira Ribeiro de. Câncer de mama no hospital universitário João de Barros Barreto: perfil clínico e epidemiológico e classificação molecular. Orientadora: Ana Karyssa Mendes Anaissi. 2023. 53 f. Trabalho de Curso (Bacharelado em Medicina) - Faculdade de Medicina, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, 2023. Disponível em: https://bdm.ufpa.br/jspui/handle/prefix/7025. Acesso em: .https://bdm.ufpa.br/jspui/handle/prefix/7025INTRODUCTION: Breast carcinoma is the main cause of cancer-related mortality in women worldwide and Brazil has high incidence and prevalence rates. OBJECTIVES: To investigate the clinical-epidemiological profile of patients, such as histopathological characteristics, molecular classification based on immunohistochemistry of breast carcinoma and response to treatment. METHODOLOGY: 320 patients had detailed medical records and, of these, 263 histopathological and immunohistochemical reports were prepared from patients treated at HUJBB from 2018 to 2022. Subsequently, the information was entered into a secure platform, REDCap (Research Electronic Data Capture ), to carry out statistical analyzes and prepare reports and tables. Data analysis explored the following variables: age, histological types, molecular classification, neoadjuvant treatment and pathological response. RESULTS: All patients were female with a mean age of 54 years. There were 220 cases of invasive carcinoma of the non-special type and 11 of invasive lobular carcinoma, the most common. Regarding molecular classification, 29.6% were Luminal B-like; 28.6% triple negative; 24.5% Luminal A type; 9.9% HER-2 positive and 7.5% Luminal B with HER-2 positive. The death rate was 16.9%. In 52 of the 98 patients undergoing neoadjuvant therapy, the pathological response was proven. A complete response was observed in 26.9%; 63.5% had an incomplete response and 9.6% had no therapeutic response. Of the 52 patients, there was no association with pathological response, number of deaths, molecular classification and histological type. CONCLUSION: Invasive carcinoma of the non-special type was the most frequent histological type, as well as the Luminal B-like and triple negative molecular profiles. Patients with a complete response had no recorded deaths. A detailed analysis of all these aspects contributes to the understanding of the disease and helps to promote improvements in diagnosis and treatment strategies.Acesso AbertoCâncer de mamaHistopatologiaClassificação molecularBreast cancerHistopathologyMolecular classificationCNPQ::CIENCIAS DA SAUDE::MEDICINATrabalho de Curso - Graduação - Monografia