2025-01-162025-01-162024-11-28FORTE, Camila Sinimbú. Investigação do perfil de expressão do CFTR em subtipos de câncer gástrico: análise de expressão diferencial, coexpressão e vias biológicas. Orientador: Gilderlanio Santana de Araújo. 2024. 44 f. Trabalho de Curso (Bacharelado em Engenharia Elétrica e Biomédica) – Faculdade de Engenharia Elétrica e Biomédica, Instituto de Tecnologia, Universidade Federal do Pará, Belém, 2024. Disponível em: https://bdm.ufpa.br/jspui/handle/prefix/7629. Acesso em:.https://bdm.ufpa.br/jspui/handle/prefix/7629To investigate the potential role of Cystic Fibrosis Transmembrane Conductance Regula tor (CFTR) gene in stomach cancer subtypes we performed differential gene expression analysis across six stomach cancer subtypes using data from the The Cancer Genome Atlas Stomach Adenocarcinoma (TCGA-STAD). Further for each cancer subtype, we explored modules of co-expressed genes using CEMiTool and over-representation analysis of functional pathways. To enhance our analysis, we integrated experimental gene-gene interaction networks and gene ontology analyses, to identify the potential role of CFTR and its interactome. Co-expression analysis demonstrated that CFTR interacts with 58 genes in the signet ring cell cancer subtype, suggesting it plays a specific role in broader regulatory networks rather than exhibiting strong, independent changes in expression levels. Despite its hypothesized role, we did not observe significant differential expression of the CFTR gene in a comprehensive analysis of 15 pairwise comparisons across six molecular subtypes of stomach adenocarcinoma for STAD-TCGA. While CFTR did not individually meet the criteria for differential expression, further investigation revealed systemic insights into its involvement in gastric cancer. CFTR may play a critical role in tumor biology by influencing the behavior of co-expressed genes and their related pathways. These findings suggest that CFTR may influence cancer progression through complex gene-gene interactions by pathway modulation.Acesso AbertoCFTR. . .Câncer GástricoRedes de coexpresãoCâncer heterogeneidadeCFTR. . .Cancer heterogeneityGastric cancerCoexpression networksCNPQ::ENGENHARIAS::ENGENHARIA BIOMEDICATrabalho de Curso - Graduação - Monografia