2026-03-202026-03-202025-04-04OLIVEIRA, Jônatan Duarte de; SILVA JÚNIOR, Reinaldo Fernandes da. Tuberculose na Amazônia legal: perfil epidemiológico, espacial e clusters de risco. Orientador: Denis Vieira Gomes Ferreira. 2025. 61 f. Trabalho de Conclusão de Curso (Bacharelado em Medicina) - Faculdade de Medicina, Campus Universitário de Altamira, Universidade Federal do Pará, Altamira, 2025. Disponível em: https://bdm.ufpa.br/handle/prefix/9390. Acesso em:.https://bdm.ufpa.br/handle/prefix/9390Introduction: Tuberculosis is an infectious disease transmitted through aerosols, caused in most cases by Mycobacterium tuberculosis. It can manifest in both pulmonary and extrapulmonary forms. The main diagnostic methods are sputum smear microscopy and culture, and treatment is provided by the Brazilian Unified Health System (SUS) using standardized regimens. Epidemiologically, tuberculosis maintains a high incidence, with an increase in notifications following the COVID-19 pandemic. The Legal Amazon is a strategic region for studying tuberculosis due to factors such as social vulnerability, population mobility, and limited access to healthcare services. Objective: To analyze the epidemiological and spatial profile of tuberculosis in the Brazilian Legal Amazon from 2019 to 2022. Methodology: A cross-sectional, retrospective study based on tuberculosis cases reported in the Legal Amazon between 2019 and 2022, extracted from the SINAN system (via TABWIN/DATASUS) and population data from IBGE. Sociodemographic, clinical, and outcome variables were analyzed. Data were processed and analyzed using Excel and RStudio, applying frequency analysis, graphs, and Chi-square tests for associations. Spatial analysis was conducted using QGIS®, with incidence maps by municipality. The study complied with the Brazilian General Data Protection Law (LGPD) and ethical standards, and approval by an ethics committee was waived due to the use of public and anonymized data. Results: The highest incidence occurred in 2022 (27.94%), especially in March (8.86%). The majority of cases were in males (67.13%), within the socially active age group, of mixed race (74.56%), and with low educational attainment. Pulmonary tuberculosis was the most common form (88.17%), while among extrapulmonary cases, pleural (4.60%) and lymph node (1.81%) forms stood out. A favorable outcome (cure) was observed in 63.74% of cases. The highest municipal incidence was recorded in Santa Izabel do Pará (486.3 cases per 100,000 inhabitants). Conclusion: Tuberculosis in the Legal Amazon remains highly incident, predominantly affecting males, individuals of mixed race, and those with low education levels. Pulmonary form is the most prevalent, and the cure rate remains below target. Unfavorable outcomes reflect existing inequalities. Spatial analysis identified critical areas, highlighting the need for regional actions and targeted interventions for vulnerable populationsAcesso AbertoTuberculosePerfil de saúdeEpidemiologiaAnálise espacialFatores de riscoTuberculosisHealth profilesEpidemiologySpatial analysisRisk factorsCNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA::PNEUMOLOGIATrabalho de Curso - Graduação - MonografiaAttribution-NonCommercial-NoDerivs 3.0 Brazil