2023-05-022023-05-022022GOMES, Luenne Talitta Correa Soares. Desmineralização óssea e risco cardiovascular em indivíduos vivendo com HIV/AIDS. Orientadora: Rosana Maria Feio Libonati. 2022. 76 f. Trabalho de Curso (Bacharelado em Medicina)-Faculdade de Medicina, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, 2022. Disponível em: https://bdm.ufpa.br:8443/jspui/handle/prefix/5589. Acesso em:.https://bdm.ufpa.br/handle/prefix/5589Introduction: The association of reduced mineral density (BMD) and cardiovascular age (CVD) have been described as a disease, regardless of genetics, and the epidemiological similarities between arterial wall calcification and osteopathy. Objective: To evaluate the association between the reduction of BMD and CVR in people living with HIV/AIDS (PLHIV) associated with the use of Antiretroviral Therapy (ART). Method: This is a cross sectional­analytical study, with 82 PLHIV individuals, of both sexes, who underwent BMD using dual­energy X­ray absorptiometry imaging of the lumbar spine (LC) and femoral neck (FC) and counting of CD4+ T cells. The RCV was estimated by the PLHIV­specific reduced data­collection on adverse effects of anti­HIV drugs (D:A:D) algorithm. Data analysis was performed using Epi­Info (version 7.2.4), Bioestat 5.3 and JAMOVI 1.6.23 software. Results: A high prevalence of reduced BMD (62.2%), CVR severity (high risk: 26.83%; very high risk 42.68%) and a high prevalence of associated risk factors (age, lipodystrophic syndrome) were found. , dyslipidemia and diabetes). An association was found between the reduction in BMD and CVR in both sexes (p=0.0207), pointing out that PLHIV in this study with bone mass loss were 3.90 times more likely to develop adverse cardiovascular events than those who does not have normal BMD. A significant negative correlation was also found between the reduction of the FC T­score (p=0.0212) and CL (p=0.0159) with the increase in the CVR. Univariate ordinal logistic regression showed an independent association between osteoporosis and CVR (p=0.042; OR: 1.30; 95% CI: 1.19–1.44). In the multivariate analysis, only age, sex and diabetes associated with increased CVR persisted. Conclusions: There is a high prevalence of reduced BMD, high CVR and common risk factors among them in PLHIV. Lower levels of BMD are associated with higher CVR in men and women PLHIV and may predict a higher risk of morbidity in this population.Acesso AbertoDensidade mineral ósseaRisco cardiovascularPVHIVBone mineral densityCardiovascular riskPLHIVCNPQ::CIENCIAS DA SAUDE::MEDICINATrabalho de Curso - Graduação - Monografia