2023-09-182023-09-182022FARIAS, Francisco Neto Pinheiro; SOUZA, Maurício Ferreira. Síndrome mão-pé-boca: análise das manifestações clínicas associadas, etiologia e epidemiologia molecular em crianças e adolescentes atendidos no setor de atendimento médico unificado (SOAMU) do Instituto Evandro Chagas/SVS/MS. Orientadora: Maria Cleonice Aguiar Justino. 2022. 106 f. Trabalho de Curso (Bacharelado em Medicina) - Faculdade de Medicina, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, 2022. Disponível em: https://bdm.ufpa.br:8443/jspui/handle/prefix/6125. Acesso em:.https://bdm.ufpa.br/handle/prefix/6125Hand-foot-mouth disease (HFMD) is a highly contagious viral disease caused by Enterovirus A71, Coxsackievirus and Echovirus. The disease is characterized by a feverish state and is accompanied by an erythematous papulovesicular eruption, which occurs predominantly in children under five years of age, but can also affect adolescents and adults. The eruption is located mainly on the hands, feet and oral mucosa, and can cause very painful ulcers that can make it difficult to ingest liquids and food. The diagnosis is made mainly through viral isolation in the feces, but molecular analyzes on swabs obtained from the oropharynx and skin lesions allow the identification of viral RNA of the enteroviruses involved. In general, the disease evolves in a benign and self limiting way in a few weeks, however there are reports in the literature of complications involving the neurological and cardiovascular systems. In Asia and the USA, the disease is notifiable, allowing the monitoring of clinical manifestations and circulating viral genotypes. In Brazil, only extensive outbreaks trigger epidemiological surveillance actions, and it is not possible to estimate the impact and profile of the disease in the country. The objective of this study was to describe the clinical and epidemiological aspects of patients with HFMD symptoms who seek the Unified Medical Care Sector (SOAMU) of the Evandro Chagas Institute (IEC), in Pará, through an observational, prospective and longitudinal study carried out from January 2019 to February 2020, and follow-up of the participants until the resolution of symptoms after performing at least three outpatient consultations at regular intervals. Stool samples, oropharyngeal swab, skin swab and blood samples were obtained for detection of enteroviruses by viral isolation and RT-PCR, respectively, performed in the Virology Section. A total of 92 participants were included in the research, of which 81% (75/92) had laboratory confirmation of the disease. Most were male (53%), predominantly brown (66%), aged between zero and five years (69%) with a predominance of cases from May to July. The predominant clinical manifestations corresponded to the presence of fever (91%), vesiculobullous lesions on the hands and feet (68%), oral ulcers (55%) and irritability (67%). Peeling of the skin was observed in 91% of the participants about 11 days after the onset of the disease with a mean duration of 17 days. Onychomadesis occurred in 37% of cases about 20 days after onset of symptoms with a mean duration of 22 days. The genotyping of the enteroviruses detected in the research observed a predominance of Coxsackievirus type A6. The present research, unprecedented in the North region, sheds light on the late clinical manifestations of HFMD, little known in the pediatric and dermatological medical community, emphasizing the importance of outpatient follow-up of these patients for a period that goes beyond the disappearance of skin lesions.Acesso AbertoSíndrome mão-pé-bocaExantemaOnicomadeseEnterovirusCoxsackievirusHand-foot-mouth diseaseSkin rashOnicomadesisEnterovirusCoxsackievirusCNPQ::CIENCIAS DA SAUDE:: MEDICINATrabalho de Curso - Graduação - Monografia