2023-03-062023-03-062022FERNANDES, Alessandro Wandel Correa. Achados eletroencefalográficos na associação álcool-benzodiazepínico. Orientador: Moisés Hamoy. 2022. 45 f. Trabalho de Curso (Bacharelado em Medicina) - Faculdade de Medicina, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, 2022. Disponível em: https://bdm.ufpa.br:8443/jspui/handle/prefix/5346 . Acesso em:.https://bdm.ufpa.br/handle/prefix/5346Introduction: The use of psychotropic drugs for recreational or therapeutic purposes have been used for most of human history. More recently, the pharmacological association between such compounds is investigated in order to understand the effects of their overdose and co-­administration, to establish disease models, and to gain insight into their toxicological and physiological consequences. Alcohol and flunitrazepam, both CNS depressants, have a wide ability to reduce anxiety, cause myorelaxation, loss of social inhibition and sedation. Their side effects can involve increased daytime sleepiness, falls, cognitive impairment and even fatal overdose. Aims: Here, our goal was to investigate the electrocorticographic alterations upon administration of alcohol and flunitrazepam in animal models (Wistar rats). Methods: For the electrode implantation process (for electrocorticographic evaluation), we established eight groups were of nine rats. We evaluated the effects of alcohol and flunitrazepam alone and in association. The animals were anesthetized with a combination of Xylazine Hydrochloride (5mg/kg) and Ketamine Hydrochloride (50mg/kg) intraperitoneally. Upon the loss of interdigital reflex, we fixed the stereotaxic device for the implantation of electrodes. To analyze the resulting signals, we built a tool implemented in Python version 2.7. Numpy and Scipy libraries were used for mathematical processing and Matplolib was employed for plotting graphics. The graphical interface was developed using the PyQt4 library. Results: Both drugs showed similar effects in reducing CNS activity. Furthermore, we observed that the association of both drugs potentiated the sedative effects and the side effects that reduce respiratory activity, with progression of such effects according to increased doses of flunitrazepam. Conclusions: In conclusion, the effects of both drugs are capable of altering waking state, cognitive and cortical functions in mice.Acesso AbertoAlterações eletrocorticográficasÁlcoolFlunitrazepamAlcoholEletrocorticographic alterationsCNPQ::CIENCIAS DA SAUDE::MEDICINATrabalho de Curso - Graduação - Monografia