2024-07-042024-07-042023-12-15SALES, Edneide Quintino; SILVA, Lucas Brelaz e. Estudos de polimorfismos funcionais nos genes abcc2 e ggh em pacientes com doença hepática crônica e carcinoma hepatocelular. Orientadora: Samia Demachki; Coorientadora: Ana Karyssa Mendes Anaissi. 2023. 81 f. Trabalho de Curso (Bacharelado em Medicina) - Faculdade de Medicina, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, 2023. Disponível em: https://bdm.ufpa.br/jspui/handle/prefix/7024. Acesso em: .https://bdm.ufpa.br/jspui/handle/prefix/7024INTRODUCTION: Hepatocellular cancer or hepatocellular carcinoma (CHC) is the 5th most common cancer in men and the 7th in women, being 4-8 times more common in men than in women, with a peak incidence of 70 years. The most important risk factor for the development of CHC is cirrhosis, with hepatitis B and C viruses being the main etiological agents involved in the development of CHC, in about 70 to 80% of cases. OBJECTIVE: To investigate the role of polymorphisms in the ABCC2 and GGH genes in patients with chronic hepatitis B and C viruses and hepatocellular carcinoma (CHC). METHODOLOGY: A cross sectional, observational and descriptive study was carried out from July 2022 to July 2023 using the RedCap system. RESULTS: 59 patients participated in this study, 69.49% were male, 2 cases (5.71%) of hepatocellular carcinoma were identified in the ABBC2 gene group (rs717620) and 1 case (4.16%) in the GGH group (rs3758149). As for the genotypic characterization of gene polymorphisms, a frequency of 80% of the C/C profile was observed in the ABCC2 gene group and a frequency of 58.3% of the A/A and A/G profiles in the GGH gene group. CONCLUSION: There was a higher prevalence of individuals diagnosed with infection by the hepatitis B and C viruses compared to other causes of chronic liver disease, most of whom were males aged over 60 years. As for the identified polymorphisms, a higher prevalence of the C/C genotypic profile was identified in patients with chronic liver diseases due to various causes, in the ABCC2 gene (rs717620), and a higher prevalence of the A/A genotypic profile, in the GGH gene (1801133) and with loss of weight, abdominal pain, bone pain and jaundice.Acesso AbertoCarcinoma hepatocelularHepatites viraisGene GGHGene ABBC2Hepatocellular carcinomaViral hepatitisCNPQ::CIENCIAS DA SAUDE::MEDICINATrabalho de Curso - Graduação - Monografia