2023-09-132023-09-132022LIMA, William de Sousa; SOARES, Marcelo Henrique Pereira. Infecção por SARS-CoV-2 e hemorragias intracranias: uma revisão sistemática com série de casos. Orientador: Fernando Mendes Paschoal Júnior. 2022. 36 f. Trabalho de Curso (Bacharelado em Medicina) - Faculdade de Medicina, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, 2022. Disponível em: https://bdm.ufpa.br:8443/jspui/handle/prefix/6109. Acesso em:.https://bdm.ufpa.br/handle/prefix/6109Introduction: COVID-19 emerged as a public health emergency around the world, causing mainly injuries to the respiratory tract. However, several evidences point to the involvement of extrapulmonary sites, including reports of intracranial hemorrhages. Objective: To describe 6 original cases and review the literature on intracranial hemorrhages in patients diagnosed with COVID-19 by molecular methods. Methods: The systematic review of the literature was made from December 19, 2021 to May 7, 2022 in the electronic databases of MEDLINE, PubMed and NCBI to identify eligible studies. Of the total of 1624 articles retrieved, only 53 articles met the inclusion criteria. Results: The overall incidence of intracranial hemorrhage in patients hospitalized for COVID 19 was 0.26%. The mean age was 60 years, with the majority being male (68%) with initial respiratory symptoms (73%) and some comorbidity. Before the diagnosis of hemorrhage, 43% were using anticoagulants, 47.3% of them in therapeutic doses. The most affected compartment was the intraparenchymal (50%), followed by the subarachnoid (34%), intraventricular (11%) and subdural (7%). There was a predominance of lobar over non-lobar topographies. Multifocal or multicompartmental hemorrhages were described in 25% of cases. Overall mortality in the cohort studies was 44%, while about 55% of patients were discharged from hospital. Conclusion: Despite the unusual association, the combination of these two diseases is associated with high rates of mortality and morbidity, as well as more severe clinical radiological presentations. More studies are needed to offer robust evidence on the exact pathophysiology behind the occurrence of intracranial hemorrhages after a COVID-19 infection.Acesso AbertoCOVID-19Infecção por SARS-CoV-2Hemorragia intracranianaHemorragia intracerebralAcidente vascular cerebral hemorrágicoSARS-CoV-2 infectionIntracranial hemorrhageIntracerebral hemorrhageHemorrhagic strokeCNPQ::CIENCIAS DA SAUDE:: MEDICINATrabalho de Curso - Graduação - Monografia