2021-08-072021-08-072020-11-13RODRIGUES, Áurea Gabriela Pereira; SOUSA, Gabriel Gomes Vilar de. Neural plasticity, healing and functionality after traumatic or chemical Achilles tendon injury. Orientadora: Suellen Alessandra Soares de Moraes. 2020. 21 f. Trabalho de Curso (Bacharel em Fisioterapia) – Faculdade de Fisioterapia e Terapia Ocupacional, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, 2020. Disponível em: https://bdm.ufpa.br:8443/jspui/handle/prefix/3426. Acesso em: .https://bdm.ufpa.br/handle/prefix/3426Introduction: Tendinopathies have multifactorial causes and the mechanisms underlying the injury and complications are still uncertain. Degenerative and inflammatory hypotheses on these mechanisms are discussed, but the late detection of the lesion may leave doubts about the processes involved. Aim: In the present study, we intended to compare the late structural and functional changes in the Achilles tendon after injury due to degeneration or inflammation. Materials and Methods: Wistar rats were divided into three groups: control, rupture and collagenase. To assess function, we measured the Achilles functional index at 0, 2, 7, 14 and 21 days post-injury. The tissue was analyzed by H&E, Bonar scale and DAPI in order to evaluate organization, vascularization and cell density. To evaluate neural plasticity, the tissue was immunolabeled with neurofilament 200 antibody and analyzed by fluorescence microscopy. Results: Tissue organization, cell morphology, number of cells and vascularization were more compromised in the rupture group. On the other hand, functional impairment and presence of nerve branches in the tissue were identified in both groups, collagenase and rupture. Conclusion: Degenerative and inflammatory lesions have very distinct structural characteristics in the late phase, although both have similar functional and neuroplastic implications.Acesso AbertoLesão tendíneaColagenase 1RupturaTendão de AquilesRegeneraçãoPlasticidade neuralCNPQ::CIENCIAS DA SAUDE::FISIOTERAPIA E TERAPIA OCUPACIONALTrabalho de Curso - Graduação - Artigo