2025-03-122025-03-122024-11-13CORREIA, Mayara Patrícia Baptista. Complicações neurológicas da síndrome congênita do zika vírus: uma revisão sistemática. Orientadora: Isabel Cristina Neves de Souza. 2024. 48 f. Trabalho de Curso (Bacharelado em Medicina) - Faculdade de Medicina, Instituto de Ciências Médicas, Universidade Federal do Pará, Belém, 2024. Disponível em: https://bdm.ufpa.br/jspui/handle/prefix/7828. Acesso em:.https://bdm.ufpa.br/jspui/handle/prefix/7828A new febrile exanthematic disease, whose manifestations did not meet the clinical criteria of other classic exanthematic diseases such as measles, rubella, scarlet fever, chickenpox, and roseola, was documented in some cities in the Northeast of Brazil. Initially, the Zika Virus presented as a self-limiting infection, being asymptomatic in 80% of cases. Simultaneously, an exponential and unexpected increase in microcephaly cases was observed in the Northeast, with Pernambuco being the epicenter. In November 2015, the causal relationship between the occurrence of microcephaly and Zika Virus infection was confirmed, leading Brazil to declare a national public health emergency. Being neurotropic, ZIKV targets neural progenitor cells, inhibiting their development and causing damage to the CNS. Objective: To identify neurological alterations and neuroimaging findings that reveal the broad spectrum of CZS and its impact on neuropsychomotor development. A systematic literature review was conducted using Google Scholar, SCIELO, and BVS platforms, including titles published from 2015 to 2023. After applying eligibility criteria and performing the analysis, 19 articles were included. Results and Discussion: Besides congenital microcephaly, a series of other neurological manifestations and functional deficiencies secondary to CNS lesions have been described in the so-called Zika Virus Congenital Syndrome (ZVCS). The main highly suggestive neurological findings were: cortical-subcortical calcifications, cortical malformations, ventriculomegaly, lissencephaly, delayed myelination, hypoplasia of the brainstem and cerebellum. The most prevalent were cerebral calcifications and ventriculomegaly, respectively. The calcifications were subcortical with a punctate pattern, distinguishing Zika Virus infection from other congenital infections. These alterations compromise the main brain functions, resulting in delays in language and motor development, abnormal sensory processing, ophthalmological and orthopedic disorders. Conclusion: Scenarios like this reinforce the need to invest in public health policies, such as identifying changes, early intervention, continuous monitoring and assistance for these patients, promoting adequate individualized treatment, to minimize the impacts of the repercussions of the disease, providing a better quality of life for these patients.Acesso AbertoComplicações neurológicasAlterações neurológicasAchados de imagemDesenvolvimento neuropsicomotorSindrome Congênita Zika VirusNeurological ComplicationsNeurological AlterationsImaging FindingsNeuropsychomotor DevelopmentZika Virus Congenital SyndromeCNPQ::CIENCIAS MEDICAS::MEDICINATrabalho de Curso - Graduação - Monografia