Association of soy and exclusive breastfeeding with central precocious puberty: a case-control study

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dc.contributor.advisor1FELÍCIO, João Soares
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/8482132737976863pt_BR
dc.contributor.advisor1ORCIDhttps://orcid.org/0000-0003-4002-988Xpt_BR
dc.creatorALCÂNTARA, Angélica Leite de
dc.creatorOLIVEIRA, Maria Clara Neres Iunes de
dc.creator.Latteshttp://lattes.cnpq.br/8249522990177010pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/8721835248482934pt_BR
dc.creator.ORCIDhttps://orcid.org/0000-0002-3973-893Xpt_BR
dc.creator.ORCIDhttps://orcid.org/0000-0002-8346-3283pt_BR
dc.date.accessioned2023-04-03T13:04:26Z
dc.date.available2023-04-03T13:04:26Z
dc.date.issued2021
dc.description.abstractIntroduction: While soy is suggested as a possible risk factor, exclusive breastfeeding (EBF) has a likely protective effect in precocious puberty. Our aim was to evaluate the association between both of these variables with central precocious puberty (CPP) Methods: We performed a retrospective, case-control study. A total of 161 girls were divided into two groups: 84 patients diagnosed with CPP composed the case group and 77 patients without the diagnosis of CPP (had gone through normal onset of puberty) were the control group. Results: Our control group had a higher presence of EBF >6 months, which was an important protective factor for CPP (OR: 0.5; IC 95%: 0.3–0.9, p = 0.05) and also correlated negatively with the presence of it (r = −0.2; p < 0.05). Oppositely, the use of soy was significantly higher in the CPP group, (OR: 3.8; IC 95%: 1.5–6, p < 0.05) and positively correlating (r = 0.2; p < 0.01) with the presence of CPP. Duration of soy intake (years) correlated with bone age (r = 0.415; p < 0.05). A logistic regression was performed to evaluate the effects of EBF duration and soy on CPP. The model was significant (x² (2) = 20,715, p = <0.001) and explained 12.2% (Nagelkerke R2) of the variance, correctly classifying 62.5% of cases. EBF was associated with a reduction of likelihood of having CPP [OR = 0,187 (CI = 0.055–0,635); Wald = 7,222, p = 0.007], while soy intake increased the risk [OR = 3.505 (CI) = 1,688–7,279, Wald = 11,319, p = 0.001]. Conclusion: Our data found the use of soy was associated with CPP. Additionally, EBF was pointed as a protective factor. However, future prospective studies are needed to clarify this issue.pt_BR
dc.identifier.citationALCÂNTARA, Angélica Leite de; OLIVEIRA, Maria Clara Neres Iunes de. Association of soy and exclusive breastfeeding with central precocious puberty: a case-control study. Frontiers in Endocrinology. [S.l.], v.12, p 1-14, jul. 2021. Disponível em: https://bdm.ufpa.br:8443/jspui/handle/prefix/5492. Acesso em:.pt_BR
dc.identifier.urihttps://bdm.ufpa.br/handle/prefix/5492
dc.rightsAcesso Abertopt_BR
dc.source.uribibsaude@ufpa.brpt_BR
dc.subjectPrecocious pubertypt_BR
dc.subjectSoypt_BR
dc.subjectEndocrine interfererpt_BR
dc.subjectExclusive breastfeedingpt_BR
dc.subjectInfantile nutritionpt_BR
dc.subject.cnpqCNPQ::CIENCIAS DA SAUDE::MEDICINApt_BR
dc.titleAssociation of soy and exclusive breastfeeding with central precocious puberty: a case-control studypt_BR
dc.typeTrabalho de Curso - Graduação - Artigopt_BR

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